• ESMO issues clinical guidelines for hereditary gastrointestinal cancers

    Emphasis is on prevention, diagnosis, treatment, and follow-up.

  • Gastric cancer prognosis: advanced stage outweighs age

    Older age is an independent risk factor only in stage I and II disease.

  • In GI neuroendocrine neoplasms with liver metastasis, primary tumor resection linked to better survival

    Consider PTR in these patients, but factor age and primary tumor site, size, and differentiation into the decision.

  • Gastric cancer: low-dose irinotecan+cisplatin offers better control in second-line

    Analysis of 2 phase 3 trials shows better PFS than high-dose irinotecan alone.

  • Autoimmune diseases and gastric cancer: is there a link?
    Autoimmune diseases and gastric cancer: is there a link?

    Meta-analysis of 52 observational studies.

  • Gastric surgery for CDH1 variants? Not so fast

    Study casts doubt on the benefit of prophylactic gastrectomy.

  • Promising new treatment for advanced refractory solid tumours
    Promising new treatment for advanced refractory solid tumours

    Further studies of the treatment for HER2-low breast cancer and other HER2-expressing cancers are planned.

  • Gastric cancer: perioperative chemo combination shows promise

    Nevertheless, the NEO-CLASSIC study did not meet its primary endpoint.

  • Lapatinib too toxic in HER2+ gastroesophageal adenocarcinoma

    First phase 2 randomized trial of add-on lapatinib with perioperative chemotherapy.

  • Gastric cancer: data fail to support routine chest CT for staging

    No solitary pulmonary metastases detected in absence of other metastatic sites.

  • PPI pendulum swings again: long-term PPI use linked to gastric cancer

    Especially use for over 36 months or after H pylori eradication.

  • ASCO 2019 — Frontline pembrolizumab offers alternative to chemotherapy in gastric/gastroesophageal junction cancers

    Gastric cancer is the fifth most frequently diagnosed cancer worldwide, with a poor outcome after surgery.

  • Laparoscopic noninferior to open distal gastrectomy for locally advanced gastric cancer

    The Chinese CLASS-01 RCT finds no differences in 3-year DFS, OS, and recurrence.

  • Gastric cancer: HIPEC + cytoreductive surgery improves survival

    Combination tops surgery alone in patients with peritoneal metastases.

  • ESMO guideline now includes FLOT for gastric cancer

    A change in the standard of care.

  • Gastric cancer: perioperative FLOT tops ECF/ECX for survival in phase 3

    Data from the FLOT4 trial.

  • Hormonal factors influencing risk of gastrointestinal cancer
    Hormonal factors influencing risk of gastrointestinal cancer

    Data from the European Prospective Investigation into Cancer and Nutrition cohort.

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