Prophylaxis is associated with increased rates of sepsis, hospitalizations.
Findings suggest this antibiotic should be used with caution among all adults age 35 years or older.
PHE annual report on trends in MRSA, MSSA, E. coli, Klebsiella spp. and P. aeruginosa bacteraemia and C. difficile infection.
Risk increases by 2- to 3-fold with sulfonamides, fluoroquinolones, macrolides, tetracyclines.