ONCOLOGY

Reducing exposure in select patients could help prevent acute and long-term toxicities.

Preoperative use indicated barring need for presurgical tumor downstaging.

Distinguishes who can avoid preoperative chemotherapy.

No overall decrease in relapse, death risks vs placebo.

Those with only WHO criterion III were at lower risk in this prospective study.

Announcements pertaining to HPV vaccination and bowel screening.

SUNSHINE trial shows potential benefit for high-dose vitamin D during chemotherapy.

By activating the bacterial SOS response, chemotherapy treatments promote antibiotic resistance and bacterial translocation.

Proton beams allow targeted delivery of higher doses with less collateral damage.

Data show recurrence in 37% of patients treated with curative intent.

Real-world data suggest effect driven by preserved hepatic function.

Risks increased for some regions, decreased for others.

Delay of 4-8 weeks bests 1-week delay for survival, tumor regression.

CCRT may be a "reasonable" option, with salvage surgery for residual disease.