A better tool for identifying high-risk tumors?
ONCOLOGY
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Content independently selected
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Cutaneous head/neck cancer: Brigham and Women’s classification outperforms AJCC 8 -
ECCMID 2019 - Cancer chemotherapy drives antimicrobial resistance by disrupting the gut microbiome By activating the bacterial SOS response, chemotherapy treatments promote antibiotic resistance and bacterial translocation.
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Melanoma: skin reactions herald dabrafenib-trametinib efficacy Immune-related skin lesions may represent a useful surrogate marker for treatment response.
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AACR 2019—Probiotics tied to poor immunotherapy response in melanoma Positive effect of high-fiber diet suggests a role for dietary manipulation.
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Stopping immunotherapy in responding melanoma: real-world outcomes Lowest risk in patients with complete response, treated over 6 months.
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AACR 2019—Fecal transplant shows benefit in refractory melanoma Clinical and radiological benefit in 2 of 3 patients with anti-PD-1 rechallenge.
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Melanoma: patient-reported outcomes stable with dabrafenib-trametinib COMBI-AD data support adjuvant use for preventing/delaying relapse.
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Merkel cell carcinoma: study identifies predictors of positive SLN Positive sentinel lymph nodes are associated with poorer survival.
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EU cancer deaths projected to continue declining in 2019 Reductions in mortality driven by lung cancer in men, breast cancer in women.
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Nodular melanoma: a distinct clinicopathological profile vs SSM Higher mortality risk for nodular subtype, even when ≤1.0 mm.
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High-risk melanoma: preoperative ctDNA predicts survival in Australian study Marker could help stratify patients for adjuvant therapy.
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Melanoma: tumor thickness tied to recurrence, distant metastasis Study sheds light on prognostic factors with surgical excision.
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Head/neck cSCC: immunosuppression tied to poor survival in Canadian meta-analysis Analysis of >3500 patients with regional lymph node metastases.
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Stage III melanoma: ctDNA predicts high risk for relapse in Australian study Assessment can help inform decisions on adjuvant therapy.