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18 Mar 2019 - UK Clinical Digest from Clin Endocrinol (Oxf) Empagliflozin treatment tied to improved metabolic profile in polycystic ovary syndrome
No effects were observed on hormonal and metabolic parameters.
18 Mar 2019 - UK Clinical Digest from Drugs Migraine: meta-analysis substantiates safety and efficacy of prophylactic erenumab
Five randomised controlled trials included in the meta-analysis.
18 Mar 2019 - Univadis Clinical Summaries from J Clin Oncol High-risk PCa: adding docetaxel to ADT+RT boosts survival
Data from the phase 3 NRG Oncology RTOG 0521 trial.

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Latest Updates

18 Mar 2019 - Univadis Clinical Summaries from J Clin Oncol HER2+ BCa brain mets: neratinib+capecitabine active in TBCRC 022
Phase 2 data show ORR of 33% to 49%, depending on prior lapatinib exposure.
18 Mar 2019 - Univadis Clinical Summaries from Int J Radiat Oncol Biol Phys DLBCL: modern systemic regimens facilitate dose-reduced RT
Only 1 local failure with 20 Gy RT.
15 Mar 2019 - Univadis Clinical Summaries from Lancet Oncol mCRC: dual HER2-targeted therapy shows benefit in MyPathway
40% response rate in KRAS wild-type, HER2-amplified disease.
15 Mar 2019 - Univadis Clinical Summaries from Cancer Treat Rev eBCa: 1-year trastuzumab tops shorter course in meta-analysis
Data show better DFS, particularly with concurrent chemotherapy.
15 Mar 2019 - International Clinical Digest from N Engl J Med HIV: 1-month rifapentine-isoniazid noninferior for preventing TB
Strategy may help promote adherence.
15 Mar 2019 - International Clinical Digest from Cochrane Database Syst Rev Probiotics for colic reduces daily crying: Cochrane
No effect on occurrence seen.
15 Mar 2019 - Oncology guidelines update from J Clin Oncol ASCO: guidelines for adjuvant therapy in biliary tract cancer
Recent randomized, controlled trials prompt new guidelines.
15 Mar 2019 - International Clinical Digest from Int J Rheum Dis RA: add-on tacrolimus noninferior to leflunomide in MTX-treated patients
Similar remission rates achieved in patients with inadequate response to MTX alone.
15 Mar 2019 - International Clinical Digest from Gastroenterology Refractory ulcerative colitis: patients respond to subcutaneous abrilumab
Tripled remission rates vs placebo in a phase 2 trial, but long-term efficacy unclear.
14 Mar 2019 - Univadis Clinical Summaries from FDA FDA approves atezolizumab/nab-paclitaxel for PD-L1+ TNBC
Accelerated approval based on frontline data from IMpassion130.
14 Mar 2019 - Univadis Clinical Summaries from Blood NHL: VEN+ R-/G-CHOP delivers high response, manageable safety
100% CR with VEN+G-CHOP in DLBCL.
14 Mar 2019 - Univadis Clinical Summaries from Breast Cancer Res Treat HR+ mBCa: palbociclib similarly effective in geriatric patients
PFS was for patients aged 70 years and older vs younger counterparts.
14 Mar 2019 - Univadis Clinical Summaries from JAMA Otolaryngol Head Neck Surg Head/neck cSCC: immunosuppression tied to poor survival in Canadian meta-analysis
Analysis of >3500 patients with regional lymph node metastases.
14 Mar 2019 - Univadis Clinical Summaries from Sci Rep Stage III NSCLC: low baseline MPV predicts poorer OS
A study of patients undergoing CCRT with cisplatin plus etoposide.

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