Recommended in Pharmacists

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How much lipid lowering on statins calls for diabetes attention?

Meta-analysis evaluated the association between LDL-c reduction and statin-induced diabetes.

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  • BMJ News
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Uni drive doubles meningitis vaccine rate

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  • BMJ News
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Aspirin for frequent tension headache queried

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  • Univadis Medical News
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Fresh Brexit concerns for European doctors

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  • Univadis Medical News
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Antidepressants double the risk of hip fracture in patients with Alzheimer’s disease

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  • Clinical Essentials from Pediatrics
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PICC lines needed on pneumonia discharge? Expert comment

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  • Clinical Essentials from Hematol Oncol
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R/R MCL: does prior transplant affect real-world ibrutinib efficacy?

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  • Clinical Essentials from Pulm Pharmacol Ther
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COPD: beclometasone dipropionate/formoterol fumarate DPI, pMDI show cardiovascular safety

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Can cardiac troponin response predict CHD risk related to statin?

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Professional & Business

  • International Medical Press

Hospitals braced for cold weather ‘spike’

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  • International Medical Press

Review raises concerns over locum doctors

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  • International Medical Press

Hospitals declare ‘black alert’ due to overcrowding

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  • International Medical Press

Former GMC chief to lead NHS Confederation

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  • International Medical Press

Plans for seven-day GPs ‘in disarray’

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  • International Medical Press

NHS warning from leading doctors and nurses

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New in Pharmacists

  • Clinical Essentials from Acta Oncol
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MCRPC: low NLR linked to improved survival with docetaxel

Neutrophil-to-lymphocyte ratio ≤3 was associated with a mean benefit in OS of almost 15 mo.

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Dementia: Monthly Essentials January 2017
  • Monthly Essentials
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Dementia: Monthly Essentials January 2017

3 meta-analyses: Benzodiazepines and Dementia | Albuminuria and Dementia | Antidepressants and Dementia

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  • Clinical Essentials from Eur Heart J
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ACS: patients with HIV have higher platelet reactivity in response to dual antiplatelet therapy

HIV-infected individuals are at higher risk for ischemic events.

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  • Clinical Essentials from Aliment Pharmacol Ther
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IBD: vitamin D levels influence response to anti-TNFs

Vitamin D has been linked to disease activity and duration of anti-TNF therapy in patients with IBD.

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  • Clinical Essentials from Cochrane Database Syst Rev
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Asthma: Cochrane review finds better outcomes with combined inhaled therapy in the ED

Benefits appear to be independent of co-treatment with corticosteroids.

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OECD critical of 'wasteful clinical care’ in new report
  • Univadis Medical News
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OECD critical of 'wasteful clinical care’ in new report

According to the OECD, more than 10 per cent of hospital expenditure is spent on correcting preventable medical mistakes or infections.

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  • Clinical Essentials from PLoS One
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HCV-4: can first-line simeprevir-PR be shortened to 12 wk?

Small phase 3 study shows 97% clearance rate in early responders with mild-moderate fibrosis.

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  • Clinical Essentials from Medicine (Baltimore)
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Head/neck mucosal melanoma: study supports adjuvant radiation for primary tumors

Adjuvant radiation of the primary tumor reduces recurrence risk, and PD-1 inhibitors improve survival in metastatic disease.

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  • Clinical Essentials from BMC Cancer
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NSCLC with brain metastases: adding temozolomide to WBRT boosts outcomes

Adding temozolamide to WBRT improved ORR, DCR, and PFS.

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  • Clinical Essentials from Eur Neurol
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Course of MS appears no worse after switch from natalizumab to DMDs

Patients with relapsing-remitting MS did not have a significant increase in relapse risk over 1 y.

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  • Clinical Essentials from J Clin Oncol
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Locally advanced urothelial carcinoma: adjuvant chemotherapy boots survival after RNU

First large-scale study of patients with upper tract urothelial carcinoma undergoing upfront radical nephroureterectomy.

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  • Clinical Essentials from J Infect Dis
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Poliovirus vaccine: fractional and full doses trigger similar boosting immune response

Use of fractional-doses could enhance affordability and stretch limited supplies.

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  • Clinical Essentials from J Am Heart Assoc
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What is the role of perioperative beta-blockers in diabetes patients undergoing noncardiac surgery?

Previous findings have conflicted, and timing has not been addressed.

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  • Clinical Essentials from J Clin Oncol
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Advanced melanoma: nivolumab demonstrates favorable safety profile

Adverse events were primarily of low-grade severity.

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