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Urine testing of hospitalized HIV patients for tuberculosis is cost-effective Compared to other diagnostic strategies, urine testing is relatively easy and inexpensive and can detect cases of TB that would have otherwise been missed
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New HIV Innovation Fund projects announced The fund from Public Health England supports innovative approaches to reaching under-served at-risk groups
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TDF-XTC backbones do not correlate with the risk of adverse pregnancy outcomes The authors conducted a pooled analysis of pregnancies in HIV-positive women from observational studies participating in the EPPICC, to investigate whether specific nucleoside reverse transcriptase inhibitor backbones are associated with risk of adverse pregnancy outcomes
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Health Secretary announces goal to end HIV transmissions by 2030 New transmissions of HIV in England can be ended in 10 years, the Health Secretary says.
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People living with HIV experience greater ageing compared to their HIV-negative counterparts Using a panel of biomarkers for ageing, researchers demonstrated that age advancement could be related to viral co-infections, historic severe immunosuppression and exposure to saquinavir
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New guidance on investigating criminal transmission of HIV Updated guidance on investigating criminal transmission of HIV has been published.
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Use of CRISPR-Cas9 gene editing technique to reduce Kaposi’s sarcoma-associated herpesvirus latency CRISPR-Cas9 has been used for the first time to successfully edit the latency-associated nuclear antigen (LANA) of the KSHV virus, and reduce viral episome burden in infected cells
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Number of places on PrEP trial to double but no date set NHS England has agreed to fund new places, but it is unclear when they will be available
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Prescribed opioids raise risk of pneumonia in patients with and without HIV A nested study published in JAMA Internal Medicine confirms the immunosuppressive effects of some opioids and the increased risk of community-acquired pneumonia in people living with HIV using opioids at higher doses
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Study finds increase in drug use and HIV-related behaviours in men who have sex with men Increase seen over a three-year period in groups from two UK cities
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Early and continuous HIV treatment offers protection against a large number of AIDS and non-AIDS related events A pooled analysis of data from SMART and START studies allows calculating the magnitude and quality of benefits of life-long antiretroviral treatment
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Sexual health commissioning to be reviewed under new NHS plan, but funding cuts threaten England’s achievements in HIV The new NHS plan will review sexual health commissioning, but HIV organisations say funding cuts are threatening England’s achievements on HIV targets
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Manipulation of latent intracellular HIV through Tat gene circuit could be an effective strategy for complete eradication The reservoir of HIV latently infected cells is the major obstacle for complete eradication of HIV. The authors suggest that the genetic switch, which causes latent HIV inside cells to begin to replicate, can be manipulated to completely eradicate the virus from the human body
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MPs warn of ‘cliff-edge’ in access to PrEP as demand in England outstrips numbers cap MPs and peers are calling on Public Health Minister Steve Brine to urgently expand access to PrEP in England as Impact Trial turns patients away
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