Brimonidine gel (Mirvaso): Risk of cardiovascular events if applied to damaged skin

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Brimonidine (Mirvaso) an α-2 adrenergic agonist available as topical gel, is indicated for the symptomatic treatment of facial erythema of rosacea in adults.

Systemic cardiovascular effects including bradycardia, hypotension, and dizziness have been reported after application of brimonidine gel. Some cases were associated with application of brimonidine gel after laser pro...