Do not use Solu-Medrone 40 mg in patients with a known or suspected allergy to cows’ milk

Access to the full content of this site is available only to registered healthcare professionals. Register to read more

Methylprednisolone, a corticosteroid indicated for treatment of wide variety of indications including allergic states, dermatological disease, and gastrointestinal diseases. Solu-Medrone 40 mg uses lactose produced from cows’ milk as an excipient and contain trace amounts of milk proteins; while other strengths of Solu-Medrone do not contain lactose.
 

Cows’ milk allergy is an adverse reaction of an immunological nature induced by cows’ milk proteins. Estimates of prevalence of cows’ milk allergy based on food challenge vary from 0% to 3%. Most children outgrow their allergy in early childhood and only a small proportion of patients remain allergic in adulthood. Cows’ milk allergy should be clearly distinguished from lactose intolerance, which is a non-immunologically mediated reaction to milk caused by a lack of the enzyme lactase in the small intestine, which breaks lactose from milk down into glucose and galactose.
 

A recent EU review reported cases of allergic reactions, including bronchospasm and anaphylaxis, in patients ...

Recommended for you

  • Drug Updates
  • 1 comment

Misoprostol vaginal delivery system (Mysodelle): reports of excessive uterine contractions

  • Drug Updates
  • 1 comment

Incidence of death and fractures reported with concomitant use of radium-223 dichloride (Xofigo▼) and abiraterone, prednisone/prednisolone

  • Drug Updates
  • no comment

Use of gadolinium-containing contrast agents like gadodiamide (Omniscan) and intravenous gadopentetic acid (Magnevist) suspended

  • Drug Updates
  • 1 comment

Eluxadoline (Truberzi▼): Risk of pancreatitis and contraindication in patients who have undergone cholecystectomy or with biliary disorders

  • Drug Updates
  • no comment

Fingolimod (Gilenya▼): Risk of serious cardiac arrhythmias

  • Drug Updates
  • no comment

Fingolimod (Gilenya▼): Risk of skin cancer, lymphoma and serious opportunistic infections

  • Drug Updates
  • 1 comment

Reports of progressive multifocal encephalopathy (PML) post-treatment with Cladribine (Litak, Leustat) for leukaemia

  • Drug Updates
  • 1 comment

Inadvertent switching between brands of tacrolimus associated with reports of toxicity and graft rejection

  • Drug Updates
  • 1 comment

Quinine: Dose-dependent effects on QT interval and drug interactions

  • Drug Updates
  • 1 comment

Patient-related factors and 3 risk-based categories should be considered while prescribing antiepileptic drugs

  • Drug Updates
  • 1 comment

Reports of some batches of gentamicin sulphate active pharmaceutical ingredient containing higher than expected histamine levels

  • Drug Updates
  • 1 comment

Gabapentin (Neurontin): Risk of developing respiratory depression without concomitant use of opioids

  • Drug Updates
  • 1 comment

Do not use Solu-Medrone 40 mg in patients with a known or suspected allergy to cows’ milk

  • Drug Updates
  • 1 comment

Clozapine associated with risk of intestinal obstruction, faecal impaction, and paralytic ileus

  • Drug Updates
  • 1 comment

Isotretinoin (Roaccutane): Risk of sexual side effects like erectile dysfunction and decreased libido

  • Drug Updates
  • 1 comment

Loperamide (Imodium): Overdoses of loperamide associated with risk of serious cardiovascular events

  • Drug Updates
  • 1 comment

Patients on warfarin should not use over-the-counter Miconazole oral gel (Daktarin)

  • Drug Updates
  • 1 comment

Revised recommendations for use of adrenaline auto-injectors post European review

  • Drug Updates
  • 1 comment

Local and systemic administration of corticosteroids: risk of central serous chorioretinopathy

  • Drug Updates
  • 1 comment

Ibrutinib (Imbruvica▼): Reported cases of ventricular tachyarrhythmia and risk of hepatitis B reactivation and opportunistic infections

  • Drug Updates
  • 1 comment

Daclizumab (Zinbryta▼) in multiple sclerosis: Review patients for liver function currently on treatment

  • Drug Updates
  • 1 comment

Nivolumab (Opdivo▼), pembrolizumab (Keytruda▼): Risk of graft rejection

  • Drug Updates
  • 1 comment

Bendamustine (Levact): Increased mortality when used in combination treatment outside the approved indications

  • Drug Updates
  • 1 comment

Brimonidine gel (Mirvaso): Risk of cardiovascular events if applied to damaged skin

  • Drug Updates
  • no comment

Yellow Card Scheme Website: Report any side effects or safety concerns with e-cigarettes and e-liquids

  • Drug Updates
  • no comment

Restrictions to manage the risk for misuse of pseudoephedrine and ephedrine to be continued

  • Drug Updates
  • 1 comment

Denosumab (Prolia, Xgeva▼): Risk of osteonecrosis of jaw and external auditory canal

  • Drug Updates
  • 1 comment

Finasteride 1 mg (Propecia): Reports of depression and suicidal thoughts in men

  • Drug Updates
  • 1 comment

Multiple sclerosis: Rebound syndrome after stopping fingolimod (Gilenya▼) or switching therapy

  • Drug Updates
  • 1 comment

Ponatinib (Iclusig▼): Risk of vascular arterial occlusion is dose-dependent