Inadvertent switching between brands of tacrolimus associated with reports of toxicity and graft rejection

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Tacrolimus, an immunosuppressant drug prescribed orally to prevent or treat organ transplant rejection. Tacrolimus has a narrow therapeutic index, and even minor differences in blood levels has potential to cause graft rejection reactions or toxicity.

In June 2012 after receiving reports of graft rejections and toxicity resulting from switchi...