Valproate (Epilim▼, Depakote▼): High risk of neurodevelopmental disability and birth defects

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Valproate (Epilim▼, Depakote▼) indicated for the treatment of epilepsy or bipolar disorder and to also to prevent migraine headaches as an unlicensed indication.

Infants born to women on valproate therapy have a 30–40% risk of neurodevelopmental disability and a 10% risk of birth defects. Valproate should not be prescribed for epilepsy or bipolar disorder in women and girls of childbearing p...