3 factors for recurrence in clinically node-negative, pathologic N1a thyroid cancer

  • Ryu YJ & al.
  • BMC Surg
  • 5 Jul 2019

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • Lymph node ratio (LNR), extrathyroidal extension (ETE), and positive LN number are associated with recurrence in patients with clinically node-negative (cN0), pathologic N1a (pN1a) papillary thyroid cancer (PTC).

Why this matters

  • Risk factors for recurrence have not been well studied in this patient subgroup.

Key results

  • 5.7% of patients experienced recurrence.
  • LNR >5 (HR, 4.794; P<.001 gross ete and>3 positive LNs (HR, 2.505; P<.001 were associated with recurrence in multivariate analysis.>
  • 5.8% of patients experienced transient hypoparathyroidism; 3.4% experienced permanent hypoparathyroidism.
  • 3.0% of patients experienced transient recurrent laryngeal nerve injury; 0.9% experienced permanent recurrent laryngeal nerve injury.

Study design

  • 1082 patients with cN0 PTC who underwent total thyroidectomy plus bilateral central neck dissection and were verified pN1a were included.
  • Funding: Chonnam National University Hospital Biomedical Research Institute.

Limitations

  • Retrospective study.
  • Influence of radioactive iodine therapy not analyzed.