- In elderly women (aged ≥65 years), digital breast tomosynthesis (DBT) outperforms digital mammography (DM) on several performance metrics: lower abnormal interpretation rate, higher positive predictive value, and higher specificity.
- There was no difference between groups in breast cancer (BCa) detection rate, but this finding may have been confounded by performance over time.
Why this matters
- This is the first study to compare DBT vs DM in elderly women.
- Findings support adoption of DBT for first-line screening in elderly women.
- Retrospective cohort comparing performance metrics in women aged ≥65 years undergoing DBT (n=20,646) vs DM (n=15,019) at Massachusetts General Hospital during 2008-2011.
- Funding: None disclosed.
- DM and DBT offered similar cancer detection rates (6.9 vs 8.2 per 1000 exams; aOR, 1.13; P=.23).
- DBT performed better than DM on the following:
- Lower abnormal interpretation rate (5.7% vs 5.8%; aOR, 0.88; P<.001>
- Higher positive predictive value 1 (14.5% vs 11.9%; aOR, 1.26; P=.03);
- Higher specificity (95.1% vs 94.8%; aOR, 1.18; P<.001>
- Invasive cancers vs in situ cancers (81.1% vs 74.4%, respectively; P=.06).
- Node-positive cancers (10.2% vs 16.6%; P=.054).
- Single-center study.