- Food-based oral food challenges are largely safe and well-tolerated among infants, with anaphylaxis a rare event.
- Infants who have peanut anaphylaxis tend to have egg allergy and severe eczema.
Why this matters
- Oral food challenges are the common approach for diagnosing suspected food allergy, but their safety in infants is not well established.
- Infants had either oral food challenge (n=50) or observed first ingestions (n=28).
- 70% were a success.
- 12% (6/50) had anaphylaxis with oral food challenge:
- None mild.
- 3 moderate.
- 3 severe.
- Epinephrine administered in all cases, with 2 doses in 3.
- With observed first ingestions, 1 case of anaphylaxis (severe), epinephrine administered.
- 6/7 of the anaphylaxis cases involved peanut challenge; the other was egg.
- No emergency department transfers or hospital admissions.
- Frequency, outcomes of oral food challenge, observed first ingestions among infants in an allergy clinic, 2017-2018.
- Relatively small population; not peer-reviewed.