Abdominal aortic aneurysm risk linked to depressive symptoms

  • Nyrønning LÅ & al.
  • J Am Heart Assoc
  • 5 Nov 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • The risk for incident abdominal aortic aneurysm (AAA) is higher in individuals with symptoms of depression than those without depressive symptoms.

Why this matters

  • Assessment of depressive symptoms in the risk evaluation of development of AAA could potentially be important when screening subgroups at increased risk of the disease.

Study design

  • Study of 59,136 participants (aged, 50-106 years; 52.4% women; median follow-up period, 13 years) with no prior diagnosis of AAA.
  • Depressive symptoms assessed using the depression subscale of the Hospital Anxiety and Depression Scale (HADS).
  • Outcome: diagnosis of AAA.
  • Funding: Department of Circulation and Medical Imaging at the Norwegian University of Science and Technology (NTNU).

Key results

  • A total of 6401 individuals (12.3%) reported depressive symptoms (HADS-D ≥8).
  • During the follow-up period, 742 incident cases of AAA (201 women) were reported.
  • Estimated proportion of individuals diagnosed with AAA was higher among those with depressive symptoms (log-rank test, P<.001>
  • People with HADS-D ≥8 vs those with HADS-D
  • smokers (34% vs 28.9%; HR, 8.72; 95% CI, 6.56-11.61; P<.001 and>
  • reported history of coronary heart disease (12.3% vs 6.9%; HR, 2.39; 95% CI, 2.00-2.85; P<.001 and hypertension vs hr ci p=".002).</li">
  • Incident AAA was >2.5 times higher among men than women (HR, 2.64; 95% CI, 2.18-3.20; P<.001>
  • Individuals with HADS-D ≥8 vs those with HADS-D

    Limitation

    • Risk of bias.
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