- The risk for incident abdominal aortic aneurysm (AAA) is higher in individuals with symptoms of depression than those without depressive symptoms.
Why this matters
- Assessment of depressive symptoms in the risk evaluation of development of AAA could potentially be important when screening subgroups at increased risk of the disease.
- Study of 59,136 participants (aged, 50-106 years; 52.4% women; median follow-up period, 13 years) with no prior diagnosis of AAA.
- Depressive symptoms assessed using the depression subscale of the Hospital Anxiety and Depression Scale (HADS).
- Outcome: diagnosis of AAA.
- Funding: Department of Circulation and Medical Imaging at the Norwegian University of Science and Technology (NTNU).
- A total of 6401 individuals (12.3%) reported depressive symptoms (HADS-D ≥8).
- During the follow-up period, 742 incident cases of AAA (201 women) were reported.
- Estimated proportion of individuals diagnosed with AAA was higher among those with depressive symptoms (log-rank test, P<.001>
- People with HADS-D ≥8 vs those with HADS-D
- smokers (34% vs 28.9%; HR, 8.72; 95% CI, 6.56-11.61; P<.001 and>
- reported history of coronary heart disease (12.3% vs 6.9%; HR, 2.39; 95% CI, 2.00-2.85; P<.001 and hypertension vs hr ci p=".002).</li">
- Risk of bias.