- A retrospective study suggests that insulin-like growth factor-1 (IGF-1) levels and glucose metabolism are associated with a paradoxical growth hormone response (an increase) to oral glucose in patients with acromegaly.
Why this matters
- A paradoxical growth hormone response to oral glucose is common in patients with acromegaly, but associated clinical characteristics were poorly understood.
- Response to oral glucose was associated with higher presurgery IGF-1 levels (P<.05 style="list-style-type:circle;">
- This difference was not significant after pituitary surgery (P=.69).
- 63 patients with acromegaly, 19 who responded to oral glucose and 44 who did not, were analyzed for associated clinical features.
- Funding: None.
- Retrospective study.
- Small patient sample size.