Acute leukemia: intervention improves physical, psychological well-being

  • Rodin G & al.
  • Support Care Cancer
  • 17 Apr 2019

  • curated by David Reilly
  • Univadis Clinical Summaries
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Takeaway

  • EASE, a novel psychological and palliative care intervention, demonstrated feasibility and efficacy in improving physical and psychological well-being in patients with newly diagnosed acute leukemia (AL).

Why this matters

  • Similar interventions have reduced psychological distress and improved quality of life in patients with solid tumors.  

Study design

  • Phase 2 study to compare usual care (UC) alone (n=20) vs UC+Emotion and Symptom-Focused Engagement (EASE; n=22), a novel psychotherapeutic intervention, in 42 patients with newly diagnosed AL.
  • Funding: Canadian Cancer Society Research Institute; Princess Margaret Cancer Centre, Princess Margaret Cancer Foundation; University Health Network, Toronto, Ontario, Canada; Ontario Ministry of Health and Long-term Care.  

Key results

  • All predefined feasibility endpoints were met.
  • EASE delivered significant reductions in outcomes including the following (P<.05 for each vs baseline style="list-style-type:circle;">
  • Pain interference at 4 and 12 weeks.
  • Clinically relevant symptoms of acute stress disorder (ASD)/threshold ASD.
  • In patients receiving UC only at 12 weeks vs at baseline:
    • Significant worsening of pain interference (P<.05>
    • Significant decrease in satisfaction with care (P<.05>
  • At 12 weeks, 7.7% of patients met DSM-IV criteria for ASD/threshold ASD with EASE vs 42.1% with UC alone (P=.05).
  • Limitations

    • Limited sample size.

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