Acute pancreatitis: do statins have a protective role?

  • Ruiz-Rebollo ML & al.
  • Pancreatology
  • 21 Jul 2019

  • International Clinical Digest
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Takeaway

  • Patients with acute pancreatitis (AP) undergoing treatment with statins are more likely to experience milder symptoms and less likely to develop local complications or systemic inflammatory response syndrome (SIRS).

Why this matters

  • AP is the most common gastroenterology-related reason for hospital admission, with 275,000 US patients hospitalized each year.

Study design

  • Researchers analyzed the health records of patients diagnosed with AP (N=356), recording statin treatment status on admission, as well as clinical, analytical, demographic, and radiological data.
  • Funding: None.

Key results

  • 101 patients (28%) were taking statins on admission.
  • 55 (15%) presented with moderate to severe pancreatitis.
  • Propensity score analysis confirmed patients with AP taking statins had a lower risk (ORs; 95% CIs) for:
    • A moderate to severe episode: 0.409 (0.192-0.872; P=.031).
    • Local complications: 0.471 (0.208-1.066; P=.11).
    • SIRS: 0.516 (0.285-0.935; P=.041).

Limitations

  • Researchers did not determine exact doses and total duration of statin exposures, consider other exposures to other drugs, or discriminate among different types of statins.

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