Acute pancreatitis: local complications predict recurrence

  • Cho JH & al.
  • Scand J Gastroenterol
  • 10 Dec 2019

  • International Clinical Digest
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Takeaway

  • Patients are more than 3 times as likely to develop recurrent acute pancreatitis (RAP) if they have a local complication such as acute peripancreatic fluid collection, pancreatic pseudocyst, acute necrotic collection, or walled-off necrosis during their first episode.
  • Men who are

Why this matter

  • Special attention and close follow-up for such patients might reduce hospital readmissions and healthcare costs.

Study design

  • Researchers studied the health records of patients with ≥1 episode of RAP (n=617; mean age, 60.6±16.8 years; 61.6% men; median follow-up, 3.2 years) to identify recurrence risk factors using Cox regression.
  • Funding: Yeungnam University.

Key results

  • During follow-up, 100 (16.2%) patients experienced RAP; 75 had 1 relapse, 12 had 2 relapses, and 13 had ≥3 relapses.
  • Causes attributed to RAP included alcohol consumption (48%) and gallstones (31%), others were recorded as idiopathic (14%) or unspecified (7%).
  • Cox regression showed factors significantly associated with RAP risk:
    • Local complications: HR, 3.334 (95% CI, 2.211-5.026);
    • Male sex: HR, 1.927 (95% CI, 1.127-3.295); and
    • Age

Limitations

  • The study was retrospective with a small sample size.
  • Short follow-ups hampered subgroup analyses.

—Craig Hicks