Acute stroke: higher C-reactive protein levels tied to poor cognitive and functional outcomes

  • Irimie CA & al.
  • J Stroke Cerebrovasc Dis
  • 25 Jul 2018

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • Higher C-reactive protein (CRP) and lower serum triiodothyronine (T3) levels were associated with stroke severity on admission.
  • Higher CRP but not T3 levels were associated with poor cognitive and functional outcomes at discharge.

Why this matter

  • A better understanding of inflammatory factors and neuroendocrine response in acute ischaemic stroke and classifying patients with poststroke into high and low-risk groups based on CRP and T3 levels may help to predict functional and cognitive outcomes.

Study design

  • 120 patients with acute ischaemic stroke were evaluated for clinical stroke severity (National Institutes of Health Stroke Scale), serum CRP and total T3 on admission.
  • Functional and cognitive outcomes were evaluated at discharge.
  • Funding: None disclosed.

Key results

  • Higher CRP (beta=.583; P=.000) and lower T3 levels (beta=−.185; P=.043) were associated with stroke severity.
  • Poor cognitive outcomes were associated with higher CRP (beta=.441; P=.000) but not with T3 levels (P=.142).
  • Higher CRP (beta=.457; P=.000) but not T3 levels (P=.100) were associated with poor functional outcomes.
  • A probability of 53.5% to predict a poor functional outcome and a probability of 80.42% to predict a poor cognitive outcome were achieved in patients with stroke at discharge using CRP and T3 levels as prognostic factors.

Limitations

  • Smaller sample size; patients with severe stroke were included.
  • Patients after discharge were not evaluated.

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