- This meta-analysis showed that 30% of patients with acute central retinal artery occlusion (CRAO) and 25% of patients with acute branch retinal artery occlusion (BRAO) presented an acute cerebral ischaemia on magnetic resonance imaging (MRI) within 7 days of diagnosis.
Why this matters
- High incidence supports the idea that patients with an acute retinal artery occlusion require an urgent neurological evaluation and brain imaging as part of the clinical management.
- Meta-analysis included 6 studies after a search on Pubmed, Medline and Cochrane library.
- Primary outcome: pooled estimate of incidence rate of acute cerebral ischaemia in CRAO, BRAO and transient monocular vision loss (TMVL) cohorts.
- Funding: None disclosed.
- The pooled estimate of incidence of cerebral ischaemia on MRI in CRAO and BRAO cohort was 0.30 (95% CI, 0.24-0.36) and 0.25 (95% CI, 0.16-0.37), respectively.
- In the TMVL cohort, acute cerebral ischaemia was detected in 11.8% of cases.
- The pooled estimate incidence of asymptomatic acute cerebral ischaemia on MRI in CRAO, BRAO and TMVL cohorts was 0.22 (95% CI, 0.16-0.28), 0.29 (95% CI, 0.20-0.41) and 0.08 (95% CI, 0.05-0.15), respectively.
- Risk of bias.
- Risk of residual cofounding.