- Lower BMI is linked to increased risk for all-cause dementia and Alzheimer dementia (AD) in patients just diagnosed with type 2 diabetes (T2D).
- Weight change is also tied to increased all-cause dementia risk after a new diabetes diagnosis.
Why this matters
- Gaps persist regarding the association among new diabetes diagnosis, dementia, and BMI.
- During 3.5-year average follow-up, 2563 events were detected (1846 AD; 381 vascular dementia).
- Vs BMI 18.5-23, all-cause dementia risk (all HRs; 95% CIs) decreased with BMI:
- 23-25: 0.80 (0.69-0.91);
- 25-30: 0.77 (0.68-0.88); and
- ≥30: 0.79 (0.63-0.99).
- All-cause dementia risk increased with decreasing BMI: P trend <.001.>
- AD risk was:
- Higher with underweight BMI: 1.59 (1.04-2.43).
- Decreased with BMI:
- 23-25: 0.79 (0.67-0.93); and
- 25-30: 0.76 (0.65-0.88); P trend <.001.>
- Baseline BMI, vascular dementia not associated.
- 1.34 (1.11-1.63) and 1.38 (1.08-1.76), respectively.
- AD risk also increased with ≥10% weight loss within 2 years: 1.26 (1.01-1.59).
- South Korean National Health Insurance Service-National Health Screening Cohort data for 167,876 people aged ≥40 years diagnosed with new-onset T2D, 2007-2012.
- Dementia severity unknown.
- Reverse causality not ruled out.