- Children with type 2 diabetes (T2D) have more rapid beta-cell deterioration than do adults with T2D, according to findings from the RISE (Restoring Insulin Secretion) medication studies comparing the 2.
- Young people in the study did not show improved or preserved function on treatment and had rapid decline with treatment withdrawal.
Why this matters
- In a statement, the authors call the differences “quite stark.”
- The children in the RISE study had deteriorating beta-cell function on and off treatment.
- Adults had improvement on treatment, although that improvement did not last with therapy withdrawal.
- Fasting glucose was similar across all treatments, but children had higher fasting insulin and C-peptide concentrations (P<.001>
- Adults also showed decreases in BMI starting at 6 months, but young people did not (P<.05>
- RISE Pediatric Medication Study compared with adult study results.
- 91 children/young people ages 10-19 enrolled, with T2D or impaired glucose tolerance (60%) for
- Treatments: 3 months insulin glargine then 9 months of metformin; 12 months of metformin only.
- Funding: National Institute of Diabetes and Digestive and Kidney Diseases; ADA; Novo Nordisk A/S and other industry; others.
- Some difference in waist-hip ratio between adults and young people.