Add-on ginger extract may relieve migraine headache

  • Martins LB & al.
  • Cephalalgia
  • 1 Jan 2018

  • curated by Deepa Koli
  • UK Clinical Digest
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Takeaway

  • Acute treatment with add-on ginger extract and ketoprofen was associated with significant relief from migraine headache vs placebo+ketoprofen.

Why this matters

  • Previous uncontrolled studies evaluated analgesic properties of ginger in acute treatment of migraine.

Study design

  • Double-blind, placebo-controlled study of 60 patients with episodic migraine with or without aura, randomly assigned to receive either 5% ginger extract (400 mg)+intravenous ketoprofen or placebo+intravenous ketoprofen.
  • Patients’ reported headache data before medication and 0.5, 1, 1.5 and 2 hours after the medication.
  • Funding: Brazilian National Council for Scientific and Technological Development.

Key results

  • Patients who received ginger extract showed improved clinical response at 1 hour (P=.04), 1.5 hours (P=.01) and 2 hours (P=.04) after medication.
  • Ginger extract was associated with significantly improved response vs placebo at 1 hour (OR, 5.09; P=.05), 1.5 hours (OR, 10.54; P=.03) and 2 hours (OR, 7.25; P=.07).
  • At 2 hours, the proportion of pain-free patients was higher among patients who received ginger extract (56.7% vs. 33.3%; P=.03).
  • Side effects did not differ between the 2 groups.

Limitations

  • Both the groups received analgesics; efficacy of ginger alone was not compared with placebo.

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