- Acute treatment with add-on ginger extract and ketoprofen was associated with significant relief from migraine headache vs placebo+ketoprofen.
Why this matters
- Previous uncontrolled studies evaluated analgesic properties of ginger in acute treatment of migraine.
- Double-blind, placebo-controlled study of 60 patients with episodic migraine with or without aura, randomly assigned to receive either 5% ginger extract (400 mg)+intravenous ketoprofen or placebo+intravenous ketoprofen.
- Patients’ reported headache data before medication and 0.5, 1, 1.5 and 2 hours after the medication.
- Funding: Brazilian National Council for Scientific and Technological Development.
- Patients who received ginger extract showed improved clinical response at 1 hour (P=.04), 1.5 hours (P=.01) and 2 hours (P=.04) after medication.
- Ginger extract was associated with significantly improved response vs placebo at 1 hour (OR, 5.09; P=.05), 1.5 hours (OR, 10.54; P=.03) and 2 hours (OR, 7.25; P=.07).
- At 2 hours, the proportion of pain-free patients was higher among patients who received ginger extract (56.7% vs. 33.3%; P=.03).
- Side effects did not differ between the 2 groups.
- Both the groups received analgesics; efficacy of ginger alone was not compared with placebo.