- Among patients with adult-onset asthma (AOA), decline in lung function is slower in the subgroup with higher levels of daily physical activity.
- Authors advise recommending daily physical activity in AOA guidelines.
Why this matters
- Consensus is lacking on best AOA treatment.
- Previous long-term studies have not addressed daily physical activity (as opposed to exercise) for asthma.
- Low- vs high-activity group:
- Between Max0-2.5 and 12-year visit, both FEV1 and FVC fell faster;
- For example, annual prebronchodilator FEV1 change/year was −58.8 vs −41.4 mL (P=.001);
- No difference in inflammatory biomarkers.
- On multivariate analysis adjusted for sex, age, BMI, atopy, medication, and smoking, low daily physical activity remained predictive of faster annual FEV1 decline (P<.001>
- As part of the single-center Seinäjoki Adult Asthma Study (SAAS) of 201 patients with AOA.
- Participants included smokers; some had comorbidities.
- Researchers compared self-reported physical activity levels at year 12 to lung function at baseline, maximum in first 2.5 years of diagnosis (Max0-2.5), and at year 12.
- Funding: Finnish nonprofits, hospitals.
- Causation not established.
- Max0-2.5 postbronchodilator values were not measured.
- Activity assessed only at 12-year mark and was not measured with accelerometers.