Advanced hypopharyngeal SCC: similar OS with ICT, CRT, surgery

  • Oral Oncol

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • A retrospective study suggests that induction chemotherapy followed by (chemo)radiotherapy (ICT), definitive chemoradiotherapy (CRT), and surgery-based therapy (SRT) are associated with similar survival outcomes for patients with stage III/IV locally advanced hypopharyngeal squamous cell carcinoma (SCC).

Why this matters

  • The ability to predict outcomes helps with patient treatment management.

Key results

  • In the total cohort, 5-year DFS was 59.4% and 5-year OS was 44%.
  • 5-year DFS was 52.7% for ICT, 52.8% for CRT, and 65.5% for SRT (P=.194).
  • 5-year OS was 44.6% for ICT, 39.6% for CRT, and 45.3% for SRT (P=.106).
  • SRT was associated with a lower final laryngeal preservation rate (44.6%) compared with ICT (71.6%) and CRT (71.7%) (P<.001>
  • Salvage surgery was associated with higher rates of postoperative pharyngocutaneous fistula/wound infections (24.2% vs 7.9%; P=.007), flap failure (12.1% vs 1.4%, P=.003), and carotid blowout (9.1% vs 0.7%; P=.023) compared with primary surgery.

Study design

  • 266 patients with stage III/IV locally advanced hypopharyngeal SCC, 74 who underwent ICT, 53 who underwent CRT, and 139 who underwent SRT, were analyzed for outcomes.
  • Funding: Korean Health Industry Development Institute; National Research Foundation of Korea.

Limitations

  • Retrospective study.