- Primary debulking surgery (PDS) was associated with improved outcomes, and neoadjuvant chemotherapy (NACT) may improve survival in those with residual disease after PDS.
Why this matters
- Not all patients with stage III or IV ovarian cancers benefit from 1 standard approach, PDS or NACT, and criteria to optimize patient selection are needed.
- Retrospective study that included 263 patients treated for stage III-IV ovarian cancers between 2003 and 2015 at an academic medical center.
- Funding: Montreal-Israel Cancer Research Foundation; Gloria Shapiro Fund; Weekend to End Women Cancers; Levy Family Fund; Astra Zeneca Inc.
- Improved PFS and OS were observed after PDS vs NACT.
- PDS patients with no residual disease after surgery had significantly better OS and PFS vs all other groups (P-values=.001); the opposite was observed for NACT patients with residual disease after interval debulking surgery.
- NACT patients with complete cytoreduction had better OS and PFS vs PDS patients who did not achieve complete cytoreduction.
- Results do not support an association of NACT with increased risk of developing platinum resistance.
- Retrospective and single-center design.