Afib along with other chronic illness linked to higher mortality risk

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  • Survival in middle-aged individuals (age, 37-73 y) with self-reported Afib was strongly correlated with the level of multimorbidity (≥2 long-term health conditions [LTCs]).
  • Over the course of a follow-up of 5-10 y, those with multimorbidity were at increased risk for death.

Why this matters

  • The findings suggest that patients with Afib and co-morbidities should be prioritized for interventions to optimise their management, which would help reduce the effect of their co-morbidities on survival.

Key results

  • 3651 participants (0.7% of the study population) reported Afib; all-cause mortality rate was 6.7% (248 participants) at 7 y.
  • Compared with participants without any co-morbid LTCs, patients with Afib with ≥4 co-morbidities had a 6-fold higher risk for mortality.
  • After adjustment for confounders, the risk for mortality was significantly higher with the presence of certain non-cardiometabolic conditions, such as COPD (HR, 3.31; 95% CI, 2.14-5.11) and osteoporosis (HR, 3.13; 95% CI, 1.63-6.01).
  • Similar association was seen with co-morbid cardiometabolic conditions such as heart failure (HR, 2.96; 95% CI, 1.83-4.80).

Study design

  • This study used data from the UK Biobank cohort (n=502,640) to compare the number and type of co-morbid LTCs and their association with all-cause mortality in participants with and without self-reported Afib.
  • Funding: Chief Scientist Office; Scotland Catalyst grant; NHS Research Scotland Career Researcher Fellowship.


  • All LTCs including Afib were self-reported.