- Both chronological aging and menopausal status contribute to the cardiovascular disease (CVD) risk profile of aging women.
Why this matters
- Increased risk for CVD mainly at the level of lipid metabolism and not BP.
- Close monitoring of changing lipid profiles in postmenopausal women may be warranted.
- Comparing postmenopausal women aged 45 y with postmenopausal women aged 50 y, younger women had lower low-density lipoprotein cholesterol (LDL) and triglycerides.
- Comparing postmenopausal and premenopausal women in the 46 to 55 y age range, postmenopausal women had higher LDL and triglycerides.
- Comparing naturally postmenopausal women with premenopausal women in the 29 to 52 y age range, BPs were lower in postmenopausal women.
- Comparing women with surgical menopause to all others in the 32 to 52 y age range, BMI, triglycerides, and LDL were higher in women with surgical menopause.
- Cohort taken from LifeLines Cohort Study, a multi-disciplinary prospective population-based cohort study of 167,729.
- 63,466 women were included and classified as premenopausal, perimenopausal, or postmenopausal and compared.
- Height, weight, BP, fasting lipids, and glucose obtained.
- Questionnaires provided data on contraception, hormonal therapy, smoking, pregnancy, and breastfeeding.
- Funding: None disclosed.
- Only associations can be made, causality cannot be determined.