Age at menopause and type of menopause have minor effect on CV risk

  • Heart

  • curated by Elisabeth Aron, MD, MPH, FACOG
  • Clinical Essentials
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Age at menopause and type of menopause likely have only a small effect on conventional cardiovascular disease (CVD) intermediates from midlife to age 69 years.

Why this matters

  • Early age at menopause is associated with increased CVD risk.
  • Data from this birth cohort analysis may reassure patients that the effect may be small.

Key results

  • Systolic BP, diastolic BP, BMI, and waist circumference trajectories from age 36 to 69 years were not statistically different by age at menopause onset or type of menopause.
  • Triglycerides, cholesterol measures, and HbA1c trajectories from age 53 to 69 years were not statistically different by either age at onset or type of menopause.

Study design

  • Birth cohort study.
  • Cohort was taken from the UK Medical Research Council (MRC) National Survey of Health and Development.
  • Data were collected longitudinally and prospectively from age 36 to 53 years and from age 36 to 69 years.
  • Conventional CVD intermediates: age at menopause, type of menopause (natural vs hysterectomy), BP, lipids, HbA1c, and BMI were examined.
  • Funding: The UK MRC; individual funding to authors.

Limitations

  • Measures not available for all women.
  • Selection bias possible.