Age of menopause affects risk for future CVD

  • Lancet Public Health

  • International Clinical Digest
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Takeaway

  • Premature and early menopause are linked to a higher risk for cardiovascular disease (CVD).

Why this matters

  • The median age of natural menopause is 51.4 years in high-income countries.
  • Strategies to reduce risks for early menopause may reduce the risk for CVD in women.
  • Women with early menopause may need increased surveillance.

Key results

  • Mean age at menopause was 50.2 years.
  • 1.2% had premature menopause (
  • Mean time from menopause to CVD was 13.5 years.
  • Women with CVD were more likely to be less educated, obese, and current smokers with a history of hypertension.
  • Risk for CVD was higher in women with premature (HR, 1.55; P<.0001 or early p menopause compared with average menopause.>

Study design

  • Retrospective cohort study.
  • Cohort was obtained from the International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events, a consortium of pooled individual-level data on reproductive health and chronic diseases for 537,153 women (n=301,438).
  • Exposure was age at menopause.
  • Primary endpoint was occurrence of first nonfatal CVD (heart attack, angina, or stroke).
  • Funding: Australian National Health and Medical Research Council.

Limitations

  • Related to the limitations of original studies.

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