- Premature and early menopause are linked to a higher risk for cardiovascular disease (CVD).
Why this matters
- The median age of natural menopause is 51.4 years in high-income countries.
- Strategies to reduce risks for early menopause may reduce the risk for CVD in women.
- Women with early menopause may need increased surveillance.
- Mean age at menopause was 50.2 years.
- 1.2% had premature menopause (
- Mean time from menopause to CVD was 13.5 years.
- Women with CVD were more likely to be less educated, obese, and current smokers with a history of hypertension.
- Risk for CVD was higher in women with premature (HR, 1.55; P<.0001 or early p menopause compared with average menopause.>
- Retrospective cohort study.
- Cohort was obtained from the International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events, a consortium of pooled individual-level data on reproductive health and chronic diseases for 537,153 women (n=301,438).
- Exposure was age at menopause.
- Primary endpoint was occurrence of first nonfatal CVD (heart attack, angina, or stroke).
- Funding: Australian National Health and Medical Research Council.
- Related to the limitations of original studies.