- Alcohol drinking among men at risk for prostate cancer is associated with a slightly lower risk of lethal disease (metastasis or death) than abstaining, according to 25-year data from a large prospective cohort.
- Lower risk of progression to lethal disease was observed with red wine consumption among men with prostate cancer.
Why this matters
- Findings suggest that moderate alcohol consumption is safe for men with and without prostate cancer.
- Prospective all-male Health Professionals Follow-up Study involving 47,568 cancer-free men at risk for prostate cancer and 5182 with nonmetastatic disease (1986-2012).
- Funding: Prostate Cancer Foundation; NIH.
- Any (vs none) alcohol intake was associated with a 16% lower risk of lethal prostate cancer (HR, 0.84; 95% CI, 0.71-0.99) among men at risk.
- Among men with prostate cancer:
- Any (vs none) alcohol intake was not associated with progression to lethal prostate cancer (HR, 0.99; 95% CI, 0.57-1.72).
- Any red wine intake (vs none) was associated with 50% reduced risk of progression (HR, 0.50; 95% CI, 0.29-0.86).
- Moderate total alcohol (15-30 g/day; vs none) was associated with lower risk of death (HR, 0.71; 95% CI, 0.50-1.00), as was any red wine (HR, 0.74; 95% CI, 0.57-0.97; Ptrend=.007).
- Observational design.
- Potential unmeasured confounders.