- Alcohol use disorder (AUD) is associated with elevated risk of developing chronic kidney disease (CKD), particularly among younger individuals.
Why this matters
- Some studies suggested a potential protective effect on renal function.
- Patients with AUD were more likely than control participants to have baseline comorbidities, including hypertension, COPD, heart failure, and diabetes (P<.001 for all vs control participants>
- CKD incidence higher among patients with AUD (per 1000 person-years: 3.48 vs 6.51; aHR=1.62; P<.001>
- Kaplan-Meier analysis also showed higher cumulative CKD incidence (log-rank test, P<.001>
- In multivariate analysis, AUD was associated with an increased risk for CKD (aHR=1.68; P<.001 after adjusting for age sex comorbidities and nsaid>
- Risk was elevated among patients with AUD aged 65 years.
- Study of 11,639 patients aged ≥20 years diagnosed with AUD and 46,556 demographically matched control participants from Taiwan’s National Health Insurance research database.
- Median follow-up: AUD group, 6.25 years; control group, 7.29 years.
- Funding: Taiwan Ministry of Health and Welfare, Children’s Hospital of China Medical University, China Medical University Hospital, Academia Sinica Taiwan Biobank Stroke Biosignature Project, Taiwan Clinical Trial Consortium for Stroke, Tseng-Lien Lin Foundation, Taiwan Brain Disease Foundation, and Katsuzo and Kiyo Aoshima Memorial Funds.
- Retrospective design.
- Lifestyle factors not captured.