Alcohol use disorder tied to higher odds of CKD

  • Pan CS & al.
  • PLoS One
  • 6 Sep 2018

  • curated by Yael Waknine
  • Clinical Essentials
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Alcohol use disorder (AUD) is associated with elevated risk of developing chronic kidney disease (CKD), particularly among younger individuals.

 Why this matters

  • Some studies suggested a potential protective effect on renal function.

    Key results

    • Patients with AUD were more likely than control participants to have baseline comorbidities, including hypertension, COPD, heart failure, and diabetes (P<.001 for all vs control participants>
    • CKD incidence higher among patients with AUD (per 1000 person-years: 3.48 vs 6.51; aHR=1.62; P<.001>
    • Kaplan-Meier analysis also showed higher cumulative CKD incidence (log-rank test, P<.001>
    • In multivariate analysis, AUD was associated with an increased risk for CKD (aHR=1.68; P<.001 after adjusting for age sex comorbidities and nsaid>
    • Risk was elevated among patients with AUD aged 65 years.

    Study design

    • Study of 11,639 patients aged ≥20 years diagnosed with AUD and 46,556 demographically matched control participants from Taiwan’s National Health Insurance research database.
    • Median follow-up: AUD group, 6.25 years; control group, 7.29 years.
    • Funding: Taiwan Ministry of Health and Welfare, Children’s Hospital of China Medical University, China Medical University Hospital, Academia Sinica Taiwan Biobank Stroke Biosignature Project, Taiwan Clinical Trial Consortium for Stroke, Tseng-Lien Lin Foundation, Taiwan Brain Disease Foundation, and Katsuzo and Kiyo Aoshima Memorial Funds.   

    Limitations

    • Retrospective design.
    • Lifestyle factors not captured.

    Please confirm your acceptance

    To gain full access to GPnotebook please confirm:

    By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

    Submit