Alcohol use disorder tied to higher odds of CKD

  • Pan CS & al.
  • PLoS One
  • 6 Sep 2018

  • curated by Yael Waknine
  • Clinical Essentials
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  • Alcohol use disorder (AUD) is associated with elevated risk of developing chronic kidney disease (CKD), particularly among younger individuals.

 Why this matters

  • Some studies suggested a potential protective effect on renal function.

    Key results

    • Patients with AUD were more likely than control participants to have baseline comorbidities, including hypertension, COPD, heart failure, and diabetes (P<.001 for all vs control participants>
    • CKD incidence higher among patients with AUD (per 1000 person-years: 3.48 vs 6.51; aHR=1.62; P<.001>
    • Kaplan-Meier analysis also showed higher cumulative CKD incidence (log-rank test, P<.001>
    • In multivariate analysis, AUD was associated with an increased risk for CKD (aHR=1.68; P<.001 after adjusting for age sex comorbidities and nsaid>
    • Risk was elevated among patients with AUD aged 65 years.

    Study design

    • Study of 11,639 patients aged ≥20 years diagnosed with AUD and 46,556 demographically matched control participants from Taiwan’s National Health Insurance research database.
    • Median follow-up: AUD group, 6.25 years; control group, 7.29 years.
    • Funding: Taiwan Ministry of Health and Welfare, Children’s Hospital of China Medical University, China Medical University Hospital, Academia Sinica Taiwan Biobank Stroke Biosignature Project, Taiwan Clinical Trial Consortium for Stroke, Tseng-Lien Lin Foundation, Taiwan Brain Disease Foundation, and Katsuzo and Kiyo Aoshima Memorial Funds.   


    • Retrospective design.
    • Lifestyle factors not captured.

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