Alcohol use disorder tied to increased all-cause mortality

  • Abdul-Rahman AK & al.
  • Subst Abus
  • 29 Jun 2018

  • from Sarfaroj Khan
  • Clinical Summaries
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Takeaway:

  • Patients with alcohol use disorder (AUD) were at increased risk for all-cause and cause-specific mortality rates compared with general populations.
  • Like the general population, cardiovascular disease (CVD) was the most likely cause of death in patients with AUD, followed by gastrointestinal and unnatural deaths.

Why this matter

  • AUDs are known to increase the relative risk for all-cause and some cause-specific mortalities but the absolute mortality rates in the AUD population are unknown.

Study design

  • Meta-analysis of 31 studies (n=36,375) that evaluated the cause-specific mortality rates in patients with AUD identified after a search across electronic databases.
  • Funding: None disclosed.

Results:

  • 6,768 all-cause deaths were recorded in 276,990.7 person-years (py) of follow-up.
  • The pooled all-cause mortality rate was 27.67 per 1000 py (95% CI, 23.9-32.04).
  • The CVD (6.9/1000py; 95%CI, 5.61- 8.49) was the most common cause of mortality followed by gastrointestinal deaths (5.63/1000 py; 95%CI, 4.1-7.74), unnatural deaths (4.95/1000 py; 95%CI, 4.01-6.09), neoplasms (4.47/1000py; 95%CI, 3.34-6.00), respiratory diseases (1.42/1000py; 95%CI, 0.96-2.10).

Limitations

  • Significant heterogeneity in estimates of pooled crude mortality rates.