- Patients with alcohol use disorder (AUD) were at increased risk for all-cause and cause-specific mortality rates compared with general populations.
- Like the general population, cardiovascular disease (CVD) was the most likely cause of death in patients with AUD, followed by gastrointestinal and unnatural deaths.
Why this matter
- AUDs are known to increase the relative risk for all-cause and some cause-specific mortalities but the absolute mortality rates in the AUD population are unknown.
- Meta-analysis of 31 studies (n=36,375) that evaluated the cause-specific mortality rates in patients with AUD identified after a search across electronic databases.
- Funding: None disclosed.
- 6,768 all-cause deaths were recorded in 276,990.7 person-years (py) of follow-up.
- The pooled all-cause mortality rate was 27.67 per 1000 py (95% CI, 23.9-32.04).
- The CVD (6.9/1000py; 95%CI, 5.61- 8.49) was the most common cause of mortality followed by gastrointestinal deaths (5.63/1000 py; 95%CI, 4.1-7.74), unnatural deaths (4.95/1000 py; 95%CI, 4.01-6.09), neoplasms (4.47/1000py; 95%CI, 3.34-6.00), respiratory diseases (1.42/1000py; 95%CI, 0.96-2.10).
- Significant heterogeneity in estimates of pooled crude mortality rates.