Allergic disease, steroid use tied to risk for Hodgkin's lymphoma

  • Rafiq M & al.
  • J Allergy Clin Immunol
  • 12 Nov 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • The risk of developing incident Hodgkin’s lymphoma (HL) is higher with prior allergic disease, especially eczema, and corticosteroid treatment.
  • This is in addition to the established risk factors of immunosuppression and infectious mononucleosis.

Why this matters

  • Findings support growing evidence that immune dysregulation, following allergic disease or immunosuppression, is central to the development of HL.

Study design

  • This was a case-control study of 1236 cases of HL and 7416 matched controls.
  • Multivariable logistic regression was used to determine ORs for associations between allergic diseases and HL after adjusting for established risk factor.
  • Funding: None.

Key results

  • Immunosuppression was associated with 6 times higher odds of developing HL (aOR, 6.18; 95% CI, 3.04-12.57; P<.001 with attenuation in the or after adjusting for steroid use.>
  • A previous diagnosis of allergic diseases and eczema alone were associated with the risk of developing HL (aOR, 1.41; 95% CI, 1.24-1.60; P<.001 and aor ci p respectively>
  • After adjusting for steroid use, these associations were decreased, but still found to be significant (aOR, 1.25; 95% CI, 1.09-1.43; P=.002; and aOR, 1.27; 95% CI, 1.08-1.49; P=.005, respectively).
  • Previous steroid use was a significant risk factor for HL development (aOR, 1.38; 95% CI, 1.20-1.59; P<.001>

Limitations

  • Risk of confounding.  
  • Risk of bias.