- The risk of developing incident Hodgkin’s lymphoma (HL) is higher with prior allergic disease, especially eczema, and corticosteroid treatment.
- This is in addition to the established risk factors of immunosuppression and infectious mononucleosis.
Why this matters
- Findings support growing evidence that immune dysregulation, following allergic disease or immunosuppression, is central to the development of HL.
- This was a case-control study of 1236 cases of HL and 7416 matched controls.
- Multivariable logistic regression was used to determine ORs for associations between allergic diseases and HL after adjusting for established risk factor.
- Funding: None.
- Immunosuppression was associated with 6 times higher odds of developing HL (aOR, 6.18; 95% CI, 3.04-12.57; P<.001 with attenuation in the or after adjusting for steroid use.>
- A previous diagnosis of allergic diseases and eczema alone were associated with the risk of developing HL (aOR, 1.41; 95% CI, 1.24-1.60; P<.001 and aor ci p respectively>
- After adjusting for steroid use, these associations were decreased, but still found to be significant (aOR, 1.25; 95% CI, 1.09-1.43; P=.002; and aOR, 1.27; 95% CI, 1.08-1.49; P=.005, respectively).
- Previous steroid use was a significant risk factor for HL development (aOR, 1.38; 95% CI, 1.20-1.59; P<.001>
- Risk of confounding.
- Risk of bias.