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Identified risk factors for Alzheimer’s disease (AD) progression suggest interactions among genetic and hormonal factors, cognitive reserve, and cerebral perfusion affecting mechanisms of neurodegeneration.
This 44-month cohort study enrolled 214 consecutive outpatients with late-onset AD (146 women).
Clinical Dementia Rating (CDR) and Mini-Mental State Examination (MMSE) measured cognitive and functional decline.
Investigators were blinded to APOE status (52.8% APOE4+ carriers).
Mean age of AD onset was 73.4±6.5, negatively correlated with time to CDR 1.0 (P<.001), MMSE=20 (P<.001), and MMSE=15 (P=.003), more significantly for women and APOE4+ carriers.
Mean schooling was 4.18±3.7 years, correlated with time to MMSE=20 and MMSE=15 for women and APOE4+ carriers.
For men only, body mass index correlated with time to MMSE=20 (P=.006).