- In early pregnancy (≤20 weeks), the risks for adverse outcomes were higher in women with low and high haemoglobin (Hb) level compared with those with normal Hb
- Restoration of Hb after 20 weeks did not improve most adverse outcome rates but was associated with a reduction in the risk for transfusion.
Why this matter
- Findings warrant research to determine why low and high Hb in early pregnancy is linked to poorer outcomes and whether these outcomes can be prevented before or during the pregnancy.
- Retrospective study of 31,906 singleton pregnancies (gestational age, 20-42 weeks) using hospital data.
- Levels of Hb at ≤20 weeks and associations with postpartum haemorrhage (PPH) and blood transfusion at birth or postnatally were assessed.
- Funding: Australian National Blood Authority Pilot Project.
- Overall, 4.0% of the singleton pregnancies had Hb
- Women with low Hb vs those with normal and high Hb (
- PPH (15.5% vs 13.4% and 14.7%; P<.05>
- transfusion (4.9% vs 2.0% and 1.7%; P<.001>
- preterm birth (
- stillbirth (2.0% vs 0.7% and 0.7%; P<.001>
- very low birthweight (
- transfer to higher care (19.7% vs 15.6% and 18.0%; P<.001>
- PPH (15.2% vs 15.8%; aRR, 0.96; 95% CI, 0.71-1.29),
- preterm birth (9.1% vs 11.7%; aRR, 0.91; 95% CI, 0.63-1.30) and
- transfer to higher care (18.7% vs 22.5%; aRR, 0.89; 95% CI, 0.70-1.14).
- Hb results were manually entered in birth data.