- Administering continuous antibiotic prophylaxis (CAP) before postnatal imaging to newborns with antenatal urinary tract dilation (AUTD) may benefit most patients.
Why this matters
- "[C]ontemporary practice patterns surrounding the use of CAP in AUTD patients vary greatly,” say researchers. "Close to 50% of providers do not use CAP at all, even in patients with a history of Grade 3 or 4 AUTD."
- Researchers studied newborns with a history of AUTD (n=494), comparing incidence of early UTI among infants who did or did not receive postnatal antibiotic prophylaxis.
- Primary outcome: incidence of UTI between birth and the first postnatal renal ultrasound evaluation (RUS).
- Funding: Harvard University; NIH; Agency for Healthcare Research & Quality; Thrasher Research Foundation.
- 32% of patients (157) received CAP.
- 1.4% (7) developed UTI before imaging: 6 without CAP vs 1 with CAP (P=.44).
- Propensity score-adjusted odds of developing UTI with CAP (vs without) were 0.93 (P=.95).
- The study was retrospective and single-center.
- Low UTI incidence may mean the study was underpowered to detect risk reduction associated with CAP.