Anti-Müllerian hormone levels predict live birth success following embryo transfer

Takeaway

• Higher anti-Müllerian hormone (AMH) concentration in follicular fluid (FF) is associated with improved odds of live birth after single embryo transfer (SET).

Why this matters

• This study supports and clarifies the link between high AMH levels and improved chance of pregnancy.

Key results

• AMH (OR, 1.134; P=.009), luteinising hormone (OR, 1.573; P=.000), and testosterone (OR 1.106, P=.041) levels were associated with odds of top-quality blastocysts, whereas follicle-stimulating hormone (OR, 0.631; P=.000) and androstenedione (OR, 0.936; P=.042) levels were inversely associated.
• FF AMH levels were associated with increased odds of live birth (OR, 1.934; P=.000).
• FF AMH levels had 91.2% sensitivity and 91.7% specificity for predicting live birth.

Study design

• 106 transferred embryos with matching FF samples were analysed for AMH and FSH levels and correlations with SET outcomes.
• Funding: National Science Centre of Poland.

Limitations

• Cross-sectional study design.
• Some patients with polycystic ovary syndrome were included, which may have biased the results.