- In patients with hypertension, the use of any antihypertensive medications (AHMs) might be associated with a reduction in the risk for dementia and Alzheimer’s disease (AD) with no significant differences by use of a specific drug class.
Why this matter
- Findings suggest future clinical guidelines for the management of hypertension should also consider the beneficial effect of AHM on dementia risk.
- 6 prospective studies including 31,090 participants (age ≥ 55 years; 15,553 with normal BP and 15,537 with high BP) met eligibility criteria.
- Funding: The Alzheimer’s Drug Discovery Foundation and others.
- During 302,490 person-years of follow-up, 3728 had incident dementia and 1741 had incident AD.
- In patients with high BP, those using any AHM were at a lower risk for dementia (HR, 0.88; 95% CI, 0.79-0.98; P=.019) and AD (HR, 0.84; 95% CI, 0.73-0.97; P=.021) vs those not using AHM.
- The risk for dementia did not differ between one drug class vs all others.
- In patients with normal BP, no significant association was observed between AHM use and incident dementia or AD (HR, 1.03; 95% CI, 0.92-1.15).
- Heterogeneity among studies.
- Risk of residual confounding.