- Antihypertensive medications show no association with pancreatic cancer risk in patients with chronic pancreatitis.
Why this matters
- Some studies had suggested that antihypertensives might act as anticancer agents, but these results indicate otherwise.
- 26.4% of patients had been taking at least 1 antihypertensive at baseline.
- Although the authors found differential risks with different antihypertensives (e.g., reduced risk with aldosterone receptor antagonists, increased risk with calcium channel blockers), they say the estimates are imprecise (wide 95% CIs).
- They conclude that they found no measurable associations of these medications and pancreatic cancer risk in these patients during a total of 60,365 person-years of follow-up.
- National registry study, Denmark, covering data from 1996 to 2012 for 8311 patients diagnosed with chronic pancreatitis, measured against antihypertensive drug use.
- Funding: Danish Cancer Society, others.
- Confounding by indication is possible, given the high rate of comorbidities in this population.
- Pancreatic cancer was relatively rare (n=153).