Antipsychotics linked to acute respiratory failure in patients with COPD

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New research published online in JAMA Psychiatry, suggests antipsychotic treatment may have “a life-threatening adverse respiratory effect”.

In the population-based study of 5,032 COPD patients, the use of antipsychotic medication was found to increase the risk of acute respiratory failure (ARF) 1.66-fold in patients with COPD. A dose-dependent trend was identified, with risk increasing from a 1.52-fold at low daily doses to almost 4-fold at high doses.

Risk was seen with both typical and atypical agents, but did vary with different drugs. Haloperidol and risperidone more than doubled the risk of ARF. Chlorpromazine and thioridazine did not appear to significantly increase risk.

There have been previous reports of serious respirat...