Antipsychotics tied to lower free thyroxine levels

  • J Psychiatr Res

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Use of antipsychotics is associated with reduced levels of free thyroxine (fT4) in patients with psychotic disorders.

Why this matters

  • This study supports prior observations linking psychotropic drugs to impaired thyroid function and suggests careful monitoring.

Key results

  • Patients with psychotic disorders had lower median fT4 (13.70 vs 14.00 pmol/L; P<.001 and higher median thyroid-stimulating hormone vs mie levels compared with healthy control patients as well increased prevalence of hypothyroid status>
  • Use of antipsychotics (P<.001 specifically quetiapine and olanzapine was associated with lower ft4 levels.>
  • Combined use of antipsychotics and other psychotropic drugs was associated with lower fT4 levels compared with antipsychotic use alone (P<.001>
  • High fT4 levels were associated with failing memory (OR, 1.09; P=.005), depression (OR, 1.09; P=.003), hypokinesia (OR, 1.12; P<.001 paraesthesias and constipation inversely associated with weight gain>

Study design

  • 1345 patients with psychotic disorders and 989 healthy control patients were analyzed for thyroid function, including levels of fT4 and thyroid-stimulating hormone (TSH).
  • Funding: University of Oslo; Research Council of Norway; KG Jebsen Stiftelsen; South East Norway Health Authority.

Limitations

  • Cross-sectional study design.
  • Only 2 biomarkers analyzed.

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