- Use of antipsychotics is associated with reduced levels of free thyroxine (fT4) in patients with psychotic disorders.
Why this matters
- This study supports prior observations linking psychotropic drugs to impaired thyroid function and suggests careful monitoring.
- Patients with psychotic disorders had lower median fT4 (13.70 vs 14.00 pmol/L; P<.001 and higher median thyroid-stimulating hormone vs mie levels compared with healthy control patients as well increased prevalence of hypothyroid status>
- Use of antipsychotics (P<.001 specifically quetiapine and olanzapine was associated with lower ft4 levels.>
- Combined use of antipsychotics and other psychotropic drugs was associated with lower fT4 levels compared with antipsychotic use alone (P<.001>
- High fT4 levels were associated with failing memory (OR, 1.09; P=.005), depression (OR, 1.09; P=.003), hypokinesia (OR, 1.12; P<.001 paraesthesias and constipation inversely associated with weight gain>
- 1345 patients with psychotic disorders and 989 healthy control patients were analyzed for thyroid function, including levels of fT4 and thyroid-stimulating hormone (TSH).
- Funding: University of Oslo; Research Council of Norway; KG Jebsen Stiftelsen; South East Norway Health Authority.
- Cross-sectional study design.
- Only 2 biomarkers analyzed.