- Intra-articular injection of autologous protein solution (APS) is safe and effective for the treatment of knee osteoarthritis (OA).
Why this matters
- There has been an interest in injection treatments for OA to stave off the need for metal resurfacing.
- Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain scores were similar between groups at all time points until 12 mo, when the APS group had significantly higher scores (P=.02).
- From baseline, both groups improved over time at 12 mo with WOMAC pain score (APS, P<.0001 control p=".0012).</li">
- No significant differences between groups in visual analog scale (P=.05); difference observed at 12 mo (P=.06)
- MRI data showed size increase from baseline in osteophytes (P=.032) and bone marrow lesions (P=.041) in control patients, whereas APS patients showed no changes.
- No differences in adverse events between groups.
- Randomized controlled trial of APS in 46 unilateral patients with knee OA.
- Researchers recorded patient-reported outcomes and adverse events from 2 wk through 12 mo follow-up.
- Funding: Biomet Zimmer.
- Small sample size.