- In this single-center study of patients with COVID-19 pneumonia, risk factors for acute respiratory distress syndrome (ARDS) and death included older age, organ dysfunction.
Why this matters
- These data could aid in prognostication and disposition decision-making.
- Median age, 51 years; 63.7% men.
- 82.1% required oxygen.
- 41.8% (n=84) developed ARDS, of whom 52.4% (n=44) died.
- Factors associated with ARDS:
- Older age: difference, 12.0 years (P<.001>
- Higher baseline temperature: difference, 0.30°C (P=.004).
- More dyspnea: difference, 33.9% (P<.001>
- More hypertension: difference, 13.7% (P=.02).
- More diabetes: difference, 13.9% (P=.002).
- Less receipt of antivirals: difference, −14.4% (P=.005).
- More receipt of methylprednisolone: difference, 49.3% (P<.001>
- Higher neutrophil counts; biomarkers of organ damage, inflammation, and coagulopathy; lower lymphocyte counts.
- Older: difference, 18.0 years (P<.001 class="">
- Found to have lower rates of high fever: difference, −31.8% (P=.007).
- Likelier to have hypertension: difference, 18.9% (P=.05).
- Less likely to receive antivirals: difference, −40.7% (P<.001>
- Retrospective single-center cohort study of adults with COVID-19 pneumonia in Wuhan, China (n=201).
- Outcomes: risk factors for ARDS, death.
- Funding: Chinese university, government funders.
- Steroid finding potentially due to confounding by indication.