- Women with rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) may have an increased risk for preterm delivery (PTD).
- Excess risk may be partly driven by disease activity in RA, and corticosteroid use in both RA and JIA.
Why this matters
- Careful monitoring is warranted during pregnancy.
- Prospective study of 657 women with RA, 170 with JIA, and 564 women without autoimmune disease.
- Women were enrolled prior to 19 weeks' gestation by the Organization of Teratology Information Specialists Autoimmune Disease in Pregnancy Project.
- Factors affecting PTD were obtained from medical records.
- Funding: AbbVie; Amgen; Bristol-Myers Squibb; Pfizer; numerous other industry sponsors; NIH.
- RA and JIA groups had elevated risk for PTD (risk ratio [RR], 2.09 [95% CI, 1.50-2.91] and 1.81 [95% CI, 1.14-2.89], respectively) relative to control group.
- PTD was associated with active RA at enrollment (adjusted RR [aRR], 1.58; 95% CI, 1.10-2.27) and anytime during pregnancy (aRR, 1.52; 95% CI, 1.06-2.18) vs inactive RA.
- PTD was not associated with active JIA vs inactive JIA.
- For both RA and JIA groups, PTD was associated with corticosteroid use in every trimester, independent of disease activity; aRRs were significant, ranging from about 2 to 5.
- Small number of PTDs.
- Small number of JIA pregnancies.