- Preimplantation genetic testing and frozen embryo transfer (PGT-FET) has several benefits on perinatal outcomes of the newborn, including lower risk of low birth weight (LBW) and preterm delivery.
- No harms resulted from biopsy of the embryo.
Why this matters
- Studies have shown differences in LBW and preterm delivery following in vitro fertilization vs natural conception.
- PGT and FET are increasingly common, but perinatal outcomes have not been studied.
- Retrospective cohort study using Society for Assisted Reproductive Technology database.
- Compared day-5 autologous FET cycles undergoing PGT (n=10,367) vs no PGT (n=39,570).
- Financial support: None.
- PGT group mean age: 35.6 vs 33.9 years no PGT (P<.01>
- Mean number of embryos transferred: PGT 1.2 vs no PGT 1.6 (P<.01>
- Primary outcome — LBW rate: PGT 16.5% vs no PGT 23.8% (adjusted risk ratio [aRR], 0.74; 95% CI, 0.66-0.83).
- Clinical pregnancy rate: PGT 64.9% vs no PGT 57.7% (aRR, 1.16; 95% CI, 1.13-1.19).
- Live birth rate: PGT 56.2% vs no PGT 46.8% (aRR, 1.25; 95% CI, 1.21-1.30).
- Multiple gestation rate: PGT 12.6% vs no PGT 21.4% (aRR, 0.68; 95% CI, 0.60-0.77).
- Could not determine day of biopsy from data set.
- Information could be missing from data set.