Association between plasma lipid levels and risk for aortic stenosis

  • Nazarzadeh M & al.
  • Eur Heart J
  • 20 Feb 2020

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • Exposure to high lipid levels, specifically low-density lipoprotein-cholesterol (LDL-C), total cholesterol and triglyceride (TG) levels, was associated with an increased risk for aortic stenosis.
  • No significant association was observed between high lipid levels and risk for aortic or mitral regurgitation.

Why this matters

  • Finding may help in clinical decision-making regarding lipid-lowering treatment which may contribute to curb the global epidemic of aortic stenosis.

Study design

  • A multivariable Mendelian randomisation (MR) study evaluated data on 157 genetic variants that have shown association with plasma lipid levels in the Global Lipids Genetics Consortium genome-wide association study and genetic association with aortic stenosis using the data from the UK Biobank.
  • Casual association between lipid parameters and aortic stenosis was evaluated using the 2-sample MR analysis.
  • Funding: None disclosed.

Key results

  • In the multivariable MR analysis, the risk for aortic stenosis was higher with per unit increase in:
    • LDL-C (OR, 1.52 [95% CI, 1.22-1.90] per 0.98 mmol/L);
    • High-density lipoprotein-cholesterol (HDL-C; OR, 1.03 [95% CI, 0.80-1.31] per 0.41 mmol/L); and
    • TG (OR, 1.38 [95% CI, 0.92-2.07] per 1 mmol/L).
  • In the 2-sample MR analysis, each unit increase in the LDL-C (OR, 1.64 [95% CI, 1.28-2.11] per 0.98 mmol/L), HDL-C (OR, 1.82 [95% CI, 1.32-2.53] per 1.10 mmol/L) and TG (OR, 1.55 [95% CI, 1.20-2.00] per 1 mmol/L) was associated with an increased risk for aortic stenosis.
  • No significant association was observed between any of the lipid parameters and aortic or mitral regurgitation.

Limitations

  • Results may have limited generalisability.