Asthma-COPD overlap affects 30% of patients with asthma or COPD

  • Hosseini M & al.
  • Respir Res
  • 23 Oct 2019

  • International Clinical Digest
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Takeaway

  • A large meta-analysis finds that the global prevalence of asthma-COPD overlap (ACO) affects 2% of the general population and up to 30% of the populations of patients with asthma or COPD.

Why this matters

  • ACO has more respiratory symptoms, more exacerbations, poorer QoL, higher mortality rate, more health care use, and higher rate of comorbidities than either asthma or COPD alone.

Study design

  • Meta-analysis of 27 population-based studies (n>1.3 million) after search of ISI Web of Knowledge, MEDLINE/PubMed, and Scopus.
  • Funding: none.

Key results

  • Pooled prevalence of ACO in the general population was 2.0% (95% CI, 1.4%-2.6%; I2=100%).
  • Pooled prevalence of asthma only in the general population was 6.2% (95% CI, 5.0%-7.4%; I2=99.8%).
  • Pooled prevalence of COPD only in the general population was 4.9% (95% CI, 4.3%-5.5%; I2=99.9%).
  • Pooled prevalence of ACO among patients with asthma was 26.5% (95% CI, 19.5%-33.6%; I2=100%).
  • Pooled prevalence of ACO among patients with COPD was 29.6% (95% CI, 19.3%-39.9%; I2=100%).

Limitations

  • High heterogeneity across studies.
  • Data found lacking for regions of Africa, Middle East, and Eastern Europe.

Limitations

  • High heterogeneity across studies.