- There are race-related differences in eosinophilic airway inflammation among asthmatic patients receiving inhaled corticosteroids (ICS).
Why this matters
- Increased risk of eosinophilic inflammation in ICS-treated (ICS+) African-Americans may reflect corticosteroid insensitivity.
- 17% of ICS+ participants had eosinophilic airway inflammation, with no significant differences between African-Americans and Caucasians.
- African-Americans with eosinophilic inflammation were twice as likely to have mixed granulocytic pattern (7% vs 3%; P=.02) and less likely to exhibit neutrophilic inflammation (71% vs 75%; P=.02).
- 36% of subjects not treated with ICS (ICS-) had eosinophilic inflammation, with no significant difference between African-Americans and Caucasians (39% vs 35%; P=.65).
- ICS- African-Americans with eosinophilic inflammation were 4 times as likely to have mixed granulocytic infl...